CosMedix Review - The Dermatology Review (2025)

The story behind Cosmedix began in 1998 when a team of aestheticians, chemists, and doctors had the idea to create medical-grade skin care products that combined natural yet effective ingredients to address common skin concerns without causing irritation. Cosmedix also focuses on using “chirally-correct” ingredients.

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-CosMedix

In case you don’t know, chirality refers to handedness, or the direction in which a molecule is rotated. So what does this mean in terms of skin care? According to Cosmedix, this means their formulas have been filtered to contain only molecules that positively interact with the skin, resulting in less irritation and more concentrated formulas capable of real change.

What are the best selling Cosmedix products?

Cosmedix formulates products for every step of your skin care routine, including cleansers, toners, serums, eye and lip care, moisturizers, sun protection, body care, exfoliators, masks, balms, and more. With so many products to choose from, you may not know where to start! That’s why we’ve gathered the top three best selling Cosmedix products and have the details below.

Cosmedix Pure C
By far the most popular product by this brand is Cosmedix Pure C. This product is actually a mixing powder of pure vitamin C (L-ascorbic acid) crystals that can be mixed with your favorite nighttime serum or moisturizer to boost results. Cosmedix Pure C is said to help firm skin and smooth wrinkles, as well as even skin tone by reducing the look of acne scars, dark spots, and hyperpigmentation. Cosmedix Pure C should only be used at night because it may cause sensitivity if you expose your skin to the sun.

ALTERNATIVES: Our favorite Vitamin C serum isCarrot & Stick The Defence Serum. It contains 3 distinct types of Vitamin C that work together to help fight free radical damage.

Cosmedix Serum 16
Cosmedix Serum 16 is an anti-aging retinol facial serum that is said to help reduce the appearance of uneven skin tone, smooth wrinkles, and boost moisture. The brand claims that unlike other retinol serums, Cosmedix Serum 16 will not cause the typical retinol side effects of redness, dryness, or irritation. This serum should only be used at night because it may cause sensitivity if you expose your skin to the sun.

The only downside of retinol is that it can often lead to side effects like skin dryness, peeling, and irritation.

That’s why we recommend thisCarrot & Stick The Retinoid Oil. It contains Hydroxypinacolone Retinoate, an ingredient that provides similar benefits with less irritation.

Cosmedix Opti Crystal
Opti Crystal is the brand’s #1 bestselling liquid crystal eye serum that is said to reduce the look of dark circles and improve the look of fine lines, wrinkles, and sagging around the eyes. Cosmedix Opti Crystal can be used both day and night.

ALTERNATIVES: If you are concerned about aging around the eyes including bags, one product we recommend isCarrot & Stick The Eye Cream.

Cosmedix ingredients: The Five A’s

Cosmedix categorizes the key ingredients found in their products into the five A’s: acids, amino acids, vitamin A, antioxidants, and ascorbic acid. We’ll talk about each of these categories in detail so you’ll know what to expect with Cosmedix skin care products.

The acids used in Cosmedix skin care products include both alpha and beta hydroxy acids. Alpha hydroxy acids (AHAs) are most well known for their ability to exfoliate the skin by targeting corneocytes (dead skin cells) in a process called corneocyte desquamation. By enhancing their breakdown and increasing the separation of skin cells, the rate of cell turnover is increased, leading to smoother, more radiant skin. Examples of AHAs in Cosmedix products include lactic, malic, and tartaric acid. The beta hydroxy acid (BHA) that Cosmedix uses is salicylic acid, which is known to exfoliate the pore lining and help reduce acne breakouts.

Cosmedix includes amino acids in their skin care products because amino acids are building blocks of peptides, which are building blocks of proteins. You need amino acids to build important skin proteins like collagen and elastin. In addition, amino acids are humectants, which means they attract and hold onto moisture, thereby keeping the skin hydrated.

Vitamin A (aka retinol) is one of the best anti-aging skin care ingredients because it has the ability to minimize the appearance of fine lines and wrinkles, improve uneven skin tone, restore skin firmness, and shrink the appearance of enlarged pores. You can find retinol in several Cosmedix skin care products, such as Cosmedix Serum 16 and Cosmedix Define Age-Defying Treatment.

Antioxidants are ingredients that help to protect the skin against free radical damage. This is important because the harmful effects of free radicals occur as direct chemical alterations of the cellular DNA, the cell membrane, and cellular proteins, including collagen. Damaged collagen manifests as signs of premature skin aging, including wrinkles, lines, and sagging skin.

The final Cosmedix ingredient we’ll discuss is L-ascorbic acid, also known as vitamin C. L-ascorbic acid provides potent antioxidant benefits and therefore protects collagen from free radical damage. L-ascorbic acid also stimulates the synthesis of new collagen in the skin. By increasing the amount of collagen in the skin, signs of aging will be diminished and the skin will appear more firm. Another benefit of L-ascorbic acid is its ability to reduce the appearance of dark spots and improve uneven skin tone. This is accomplished through inhibition of melanin synthesis. Melanin is a pigment that gives our skin color, but too much of this pigment can lead to undesirable dark spots called hyperpigmentation. L-ascorbic acid decreases melanin formation by inhibiting tyrosinase, an enzyme that is required for melanin synthesis. The result is skin that appears brighter with less dark spots and a more even skin tone.

Where is Cosmedix sold?

Cosmedix skin care products are only sold on the brand’s website and through authorized professional partners. You can use the store locator on the brand’s website to find a spa location that sells Cosmedix products near you.

Is Cosmedix cruelty free?

Cosmedix is cruelty free. The brand does not test finished products or ingredients on animals, and neither do their suppliers or any third-parties. In addition, Cosmedix does not sell their products where animal testing is required by law.

Cosmedix reviews

Cosmedix reviews on the brand’s website are overall very positive, with most products receiving 4 and 5 star ratings. Cosmedix Pure C reviews rave about how this product really does help with hyperpigmentation and brightening the skin tone. There really aren’t many negative Cosmedix reviews. The ones we did find were concerning the Cosmedix Opti Crystal eye serum. Some customers found this serum to be too greasy, and others said it produced no noticeable difference.

What Are The Best Alternatives?

If you’re looking for skincare products to address the signs of aging, we recommendCarrot & Stick. Carrot & Stick maximizes the use of powerful ingredients and minimizes the use of superficial ones, resulting in advanced skincare solutions that help promote healthy, more youthful-looking skin. We recommend Carrot & Stick The Repair Serumfollowed byThe Moisturizer.

CosMedix Review - The Dermatology Review (2025)

FAQs

What celebrities use COSMEDIX? ›

But that doesn't mean they get glowing using only their own products; in its over two decades on the market, Cosmedix — founded by nurse practitioners and aestheticians — has attracted a celebrity following including the likes of Kim Kardashian, Victoria Beckham and Alix Earle.

What percentage of retinol is in COSMEDIX define? ›

Designed to be the first skincare product in your retinol journey, this face cream is formulated with 2% AGP Retinol Complex and Alpha Hydroxy Acids, making it gentle enough for all skin types.

What is the difference between COSMEDIX and COSMEDIX elite? ›

The regular line of COSMEDIX products features skincare with clinical-level ingredients to help you get the smoother, healthier-looking skin you crave. The Elite collection is similar to the regular line of COSMEDIX products but with higher levels of ingredients!

When was COSMEDIX created? ›

Founded in 1998 by a team of aestheticians, chemists and doctors, Cosmedix are USA owned and manufactured in Canada. The goal was to create medical-grade products that were not only natural, but effective in addressing common skin concerns, without causing irritation.

What does Oprah use for her skin? ›

Oprah loves the Dew Revive Hydration Stick. She called it, a “multipurpose balm that adds glow.” While some will try any trick to get rid of oily skin, those with dry patches know the struggle of trying to add a glow to their complexion—minus the excess oil. This product claims to quench dry skin and add dewiness.

What skin care products does Angelina Jolie use? ›

When Jolie travels—which she does often—she takes along the Dermbasics RR Perfection Cream from Rand's line Dermbasics. “It's a chemical-free antioxidant sunscreen and that's a good thing to travel with,” she says. “We also have another product she likes and takes with her: Dermbasics Glycolic Acid Pads 20%.

What is the highest grade retinol? ›

High-strength retinol – 0.3%-1%

Look for formulations with a percentage between 0.3% and 1%, with retinol 1% being the strongest option. Our strongest products are Clinical 1% Retinol Treatment and 1% Retinol Booster.

What is stronger than retinol 1%? ›

For the purposes of skin care, tretinoin can be thought of as a more concentrated version of retinol. This means that tretinoin is stronger than retinol. This difference in strength can help guide your decision-making when it comes to choosing a skin care product.

What percentage is medical grade retinol? ›

Example: Retinoids

ZO Skin Health's retinol cream, in contrast, has a similar moderate strength version at 0.5% retinol, but also a 1% formulation. Similarly, other medical grade products such as Skinceuticals has a high concentration retinol 1% option.

What is the most dermatologist recommended brand? ›

What is the number one dermatologist-recommended brand? La Roche-Posay has the honor of being the number one recommended dermatologist brand of skin care. The French skincare brand is known for its dermatologist-tested and recommended products that address a number of skin conditions and types.

What is the best dermatology recommended vitamin C serum? ›

The Best Vitamin C Serums Recommended by Dermatologists
  • Blu Atlas Vitamin C Serum. ...
  • Glow Recipe Guava Vitamin C Dark Spot Serum. ...
  • SkinCeuticals C E Ferulic with 15% L-Ascorbic Acid. ...
  • Sunday Riley C.E.O. 15% Vitamin C Brightening Serum. ...
  • Dr. ...
  • La Roche-Posay Pure Vitamin C Face Serum. ...
  • Biossance Squalane + Vitamin C Dark Spot Serum.
Dec 1, 2023

Is COSMEDIX natural? ›

COSMEDIX combines the very best of science and nature including plant-based actives and pure essential oils to deliver powerful results without excessive irritation.

How much retinol is in COSMEDIX? ›

All Ingredients

Formulated with 16% Microencapsulated Retinol Complex, this Rapid Renewal Serum combines hydration with Retinol and Retinal to help improve the appearance of an uneven skin tone and smooth the look of fine lines and wrinkles.

What is the difference between refine and define COSMEDIX? ›

Refine is used in the same way as Define, PM only and introduced gradually into your routine. The key difference with Refine (besides having a higher % of retinol) is that is does not contains any AHA's. Refine can be used alongside CosMedix Defy, which contains the same AHA blend as Define.

What does COSMEDIX do? ›

Restore, Hydrate and Balance Skin

Discover the vibrant Exfoliating Facial Cleanser that gently lifts away dirt, oil and pore-clogging impurities.

Who uses cosmedix? ›

Be that as it may, the brand has landed further than just in the hands of professionals; even celebrities are hooked on using the brand in their own routines, including Hailey Bieber, Victoria Beckham and Kim Kardashian.

What is the most successful celebrity SkinCare brand? ›

Using data sourced from Statista, digital marketing experts analysed the revenue made by the top 10 highest-earning celebrity beauty brands in 2023. The brands were then ranked from most to least revenue made. Fenty Beauty by Rihanna is the most successful celebrity beauty brand, with revenue of US$602.4 million (RM2.

What brand of makeup do most celebrities use? ›

The Most Popular Red-Carpet Makeup Brands
  • Chanel Beauty. Chanel Beauty has gone viral across social media, largely for their universally flattering lip products, and as it turns out, the brand is equally as popular amongst celebrities on the red carpet. ...
  • Dior Beauty. ...
  • Pat McGrath Labs. ...
  • Charlotte Tilbury. ...
  • L'Oréal Paris. ...
  • Lancôme.
Mar 13, 2024

What skin care brand do celebrities use? ›

Alia Bhatt is partial to the D'You balm, while Emma Roberts prefers the milky texture of Biologique Recherche Lait Vip O2. Arsema Thomas sticks with African Black Soap, while Kathryn Newton is a “double cleanse kind of girl” who uses Epicuren Herbal and Earthen SkinCare to get the job done.

References

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